London: A new study has suggested that a protein involved in the growth and development of brain cells could also play a role in depression and provide a possible target for antidepressants. Ron Duman and colleagues at Yale University compared post-mortem brain samples from 21 people who had been depressed and 18 people of the same age.The group looked for differences in gene expression by comparing levels of messenger RNA-the middle-man between gene and protein production-throughout the entire genome, reports New Scientist. While Duman’s team found several hundred differences, most striking were levels of mRNA for a particular protein, MKP-1, which inhibits a pathway involved in neural growth and development.
The brains of people with depression contained twice the amount of other people. When the group over-expressed the gene for MKP-1 in the brains of healthy rats, the animals began to show signs of depression, which disappeared when treated with an antidepressant.source(ANI)
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